Sidharth V. Puram

This study identifies high-avidity TCR signaling via NFAT as a key driver of NKG2A-positive CD8 T cell exhaustion in human tumors, with implications for immunotherapy.

This study identifies how the N-terminus of p63 isoforms mediates differential cofactor interactions, influencing transcriptional activity and apoptosis regulation.

This study uses scRNA-seq to analyze HPV-related multiphenotypic sinonasal carcinoma and finds an association between HPV and MYB expression, with potential prognostic implications.

The paper develops and applies a scalable method to map transcription factor binding in human T cells, revealing novel regulatory dynamics and gene targets.

The paper curates a large collection of cancer single-cell RNA-seq datasets, providing a comprehensive resource for analyzing tumor heterogeneity and gene expression patterns across 40 cancer types.

This paper introduces EVAsc, a method to analyze expression variation in scRNA-seq data to quantify tumor heterogeneity across cell types, subtypes, and patients.