Avishai Gavish

Dysregulated Microglial Synaptic Engulfment in Diffuse Midline Glioma

This study investigates how microglial synaptic engulfment is dysregulated in diffuse midline glioma, leading to imbalanced excitatory-inhibitory synapse ratios and increased neuronal hyperexcitability.

Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling

This study shows that cholinergic neuron activity promotes both healthy OPC and DMG proliferation through muscarinic receptors, with specific nuclei driving growth in different brain regions.

The Curated Cancer Cell Atlas: comprehensive characterisation of tumours at single-cell resolution

The paper curates a large collection of cancer single-cell RNA-seq datasets, providing a comprehensive resource for analyzing tumor heterogeneity and gene expression patterns across 40 cancer types.

GABAergic neuron-to-glioma synapses in diffuse midline gliomas

This study identifies functional GABAergic neuron-to-glioma synapses in diffuse midline gliomas that promote tumor proliferation and shows that drugs modulating GABAergic signaling affect glioma growth.

From pseudotime to true dynamics: reconstructing a real-time axis for T cells differentiation

The paper introduces a method to reconstruct real-time dynamics from single-cell trajectories by estimating cell density, flux, division, and apoptosis rates, validated on mouse thymus data.