Charles J. Frazier

This study investigates how VTA dopamine neuron activity influences decision-making under risk of punishment in rats, finding that their activity scales with punishment probability and intensity and causally affects subsequent choices.

This study uses optogenetic inhibition to examine how medial prefrontal cortex influences intertemporal choice in young and aged rats, finding age-specific effects on reward preference.

This study investigates the effects of muscarinic type 1 receptor activation on principal neurons in the rat basolateral amygdala using electrophysiological recordings.

The paper introduces an anesthetized rat model to assess organophosphate countermeasures by monitoring EEG and respiratory rate, complementing an existing in vitro assay.

The paper investigates the neural circuits and cell-specific contributions to risk-taking behavior in male and female rats during decision-making tasks involving punishment.

This study shows that dendritic membrane resistance in oxytocinergic magnocellular neurons modulates activity-induced calcium influx, impacting central oxytocin release.

This study shows aging changes how the basolateral amygdala (BLA) influences intertemporal decision making, with BLA inactivation affecting impulsivity differently in young and aged rats.

This study shows that endogenous oxytocin inhibits hypothalamic CRH neurons during acute hypernatremia, reducing stress responsiveness through Oxtr-dependent mechanisms.

This study uses optogenetics to show that basolateral amygdala activity at different decision-making phases influences risky choice in rats.