Author

Scott W. Harden

University of FloridaORCID 0000-0002-0757-1979Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:rat· 6 Assay:electronic health records· 3 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Charles J. FrazieriD· 7 shared Barry SetlowiD· 4 shared Jennifer L. BizoniD· 4 shared Alexa-Rae Wheeler· 3 shared Todd J Sahagian· 3 shared Caesar M. HernandeziD· 2 shared Caitlin A. OrsiniiD· 2 shared Eric G. KrauseiD· 2 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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7 shared papersNeuroscience

Charles J. FrazierORCID

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Author profile →

7 papers

Recent·Most cited

Optogenetic inhibition reveals distinct contributions of medial prefrontal cortex to intertemporal choice in young and aged rats

Mojdeh Faraji, Caesar M. Hernandez, Alexa-Rae Wheeler, Todd J Sahagian, Scott W. Harden, Charles J. Frazier, Matthew R. Burns, Barry Setlow, Jennifer L. Bizon

This study uses optogenetic inhibition to examine how medial prefrontal cortex influences intertemporal choice in young and aged rats, finding age-specific effects on reward preference.

Cerebral Cortex · Oct 1, 2025Peer-reviewedNeuroscience

Muscarinic type 1 receptor activated effectors in principal neurons of the rat basolateral amygdala

Todd J Sahagian, Scott W. Harden, Jennifer L. Bizon, Barry Setlow, Charles J. Frazier

This study investigates the effects of muscarinic type 1 receptor activation on principal neurons in the rat basolateral amygdala using electrophysiological recordings.

DOAJ (DOAJ: Directory of Open Access Journals) · Jan 1, 2025Peer-reviewedNeuroscience

An anesthetized rat assay for evaluating the effects of organophosphate-based compounds and countermeasures on intracranial EEG and respiratory rate.

Jeffrey S. Thinschmidt, J.D. Talton, Scott W. Harden, Charles J. Frazier

The paper introduces an anesthetized rat model to assess organophosphate countermeasures by monitoring EEG and respiratory rate, complementing an existing in vitro assay.

Frontiers in Drug Discovery · Jul 22, 2024Peer-reviewedNeuroscience

Circuit and cell-specific contributions to decision making involving risk of explicit punishment in male and female rats.

Leah M. Truckenbrod, Sara M. Betzhold, Alexa-Rae Wheeler, John Shallcross, Sarthak M. Singhal, Scott W. Harden, Marek Schwendt, Charles J. Frazier, Jennifer L. Bizon, Barry Setlow, Caitlin A. Orsini

The paper investigates the neural circuits and cell-specific contributions to risk-taking behavior in male and female rats during decision-making tasks involving punishment.

Journal of Neuroscience · Jun 7, 2023Peer-reviewedNeuroscience

Dendritic membrane resistance modulates activity-induced Ca2+ influx in oxytocinergic magnocellular neurons of mouse PVN

Wanhui Sheng, Scott W. Harden, Yalun Tan, Eric G. Krause, Charles J. Frazier

This study shows that dendritic membrane resistance in oxytocinergic magnocellular neurons modulates activity-induced calcium influx, impacting central oxytocin release.

eLife · Jul 12, 2021Peer-reviewedNeuroscience

Aging alters the role of basolateral amygdala in intertemporal choice

Caesar M. Hernandez, Caitlin A. Orsini, Chase C Labiste, Alexa-Rae Wheeler, Tyler W. Ten Eyck, Matthew M. Bruner, Todd J Sahagian, Scott W. Harden, Charles J. Frazier, Barry Setlow, Jennifer L. Bizon

This study shows aging changes how the basolateral amygdala (BLA) influences intertemporal decision making, with BLA inactivation affecting impulsivity differently in young and aged rats.

bioRxiv · Feb 21, 2019 · PreprintNeuroscience

Endogenous oxytocin inhibits hypothalamic stress responsive neurons following acute hypernatremia

Dipanwita Pati, Scott W. Harden, Kyle B. Kelly, Annette D. de Kloet, Eric G. Krause, Charles J. Frazier

This study shows that endogenous oxytocin inhibits hypothalamic CRH neurons during acute hypernatremia, reducing stress responsiveness through Oxtr-dependent mechanisms.

bioRxiv · Feb 7, 2019 · PreprintNeuroscience