Natalia Vicente

Titin cleavage in living cardiomyocytes induces sarcomere disassembly but does not trigger cell proliferation

This study shows that inducing sarcomere disassembly in cardiomyocytes via titin cleavage does not lead to cell proliferation, suggesting additional factors are needed for cardiomyocyte division.

Pathological stiffening by crosslinking glycation of titin

This study shows that glycation of cardiac titin increases in diabetes, leading to protein and cardiomyocyte stiffening through crosslinking advanced glycation end products.

Titin cleavage is a driver of cardiomyocyte disengagement and reactive myocardial fibrosis

This study shows that titin cleavage drives cardiomyocyte disengagement and fibrosis in heart disease, contributing to myocardial remodeling.