Miguel Ángel López-Unzu

Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy

This study shows that myosin inhibition with mavacamten is effective in treating HCM caused by both truncating and missense variants in MYBPC3, despite different pathomechanisms.

Titin cleavage in living cardiomyocytes induces sarcomere disassembly but does not trigger cell proliferation

This study shows that inducing sarcomere disassembly in cardiomyocytes via titin cleavage does not lead to cell proliferation, suggesting additional factors are needed for cardiomyocyte division.

Titin cleavage is a driver of cardiomyocyte disengagement and reactive myocardial fibrosis

This study shows that titin cleavage drives cardiomyocyte disengagement and fibrosis in heart disease, contributing to myocardial remodeling.

Unraveling the Molecular Complexity of Bicuspid Aortopathy: Lessons from Comparative Proteomics

The paper identifies molecular pathways and biomarkers associated with bicuspid aortopathy using proteomics in a hamster model and patient studies.