Hongwei Wang

This paper introduces a dual-affinity PNA (daPNA) platform that targets miR-21 precursor, inhibits Dicer activity, and rescues PTEN expression by blocking miR-21 maturation.

This paper introduces daPNAs, a programmable platform combining dbPNAs and asPNAs to target RNA junctions, demonstrating their use in inhibiting Dicer and regulating ribosomal frameshifting.

This study characterizes the temporal landscape of A-to-I editing in mouse retina development and shows its dynamic interplay with splicing and translation.

This study identifies widespread translational regulation during mouse retinal development, revealing dynamic translational changes and novel micropeptides involved in retinal function.

This study quantifies translational regulation in six mouse tissues across development, identifying spatiotemporal patterns of gene expression and new translational components.

riboCIRC provides a database of translatable circRNAs with computational predictions, experimental validations, and cross-species conservation analysis.