Author

Ruiyu Lin

Chinese University of Hong Kong, Shenzhen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3

Frequent Co-Authors

Gang CheniD· 3 shared Manchugondanahalli S. KrishnaiD· 3 shared Rongguang LuiD· 3 shared Xuan ZhaniD· 3 shared Yun Lian· 3 shared Desiree‐Faye Kaixin Toh· 2 shared Guobao LiiD· 2 shared Hanting Zhou· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Gang ChenORCID

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3 papers

Recent·Most cited

A new dual-affinity peptide nucleic acid for targeting miRNA-21 precursor rescues tumor repressor PTEN expression

Yun Lian, Anni Wang, Ruiyu Lin, Xin Ke, Xuan Zhan, Rongguang Lu, Tingli Qian, Arpita Ghosh, Alan Ann Lark Ong, Desiree‐Faye Kaixin Toh, Kiran M. Patil, Manchugondanahalli S. Krishna, Clément Dezanet, Jean‐Luc Décout, Souvik Maiti, , Gang Chen

This paper introduces a dual-affinity PNA (daPNA) platform that targets miR-21 precursor, inhibits Dicer activity, and rescues PTEN expression by blocking miR-21 maturation.

Cell Reports Physical Science · Nov 1, 2025Peer-reviewedMolecular Biology

Towards the Development of Isoenergetic Peptide Nucleic Acid Based Probes Targeting Double-Stranded RNAs Through Enhancing Sequence-Specific Stacking Interactions

Rongguang Lu, Kun Xi, Ruiyu Lin, Manchugondanahalli S. Krishna, Yanyu Chen, Xuan Zhan, Honghao Zeng, Xue Li, Shijian Fan, Hanting Zhou, Wenzheng Wu, Yun Lian, Yuze Dai, Lizhe Zhu, Guobao Li, Gang Chen

This paper investigates how modifying PNA with s2U adjacent to Q residues enhances binding affinity and functional activity toward dsRNAs, demonstrating broader applicability in targeting structured RNA structures.

bioRxiv · Jun 28, 2025 · PreprintBiochemistry

Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform

Rongguang Lu, Liping Deng, Yun Lian, Xin Ke, Lixia Yang, Kun Xi, Alan Ann Lerk Ong, Yanyu Chen, Hanting Zhou, Zhenyu Meng, Ruiyu Lin, Shijian Fan, Yining Liu, Desiree‐Faye Kaixin Toh, Xuan Zhan, , Gang Chen

This paper introduces daPNAs, a programmable platform combining dbPNAs and asPNAs to target RNA junctions, demonstrating their use in inhibiting Dicer and regulating ribosomal frameshifting.

Cell Reports Physical Science · Aug 12, 2024Peer-reviewedBiochemistry