Max Larsson

This study identifies fast-conducting mechano-nociceptors as essential for mechanical nocifensive behaviors and sensitization in mice and humans.

The paper shows that TRPV1+ afferents rapidly reprogram TRPV1- Aβ afferents, leading to hyperalgesia in humans.

The paper maps nociceptive signaling architecture by combining activity labeling with single-cell RNA sequencing, revealing a hierarchical organization of mechano-nociceptor populations based on tissue domain and organ context.

The paper introduces a new mouse line expressing FlpO recombinase specifically in NaV1.8-expressing sensory neurons, enabling selective intersectional targeting of C-fiber mechanoreceptors and nociceptors.

This paper introduces a new NefhCreERT2 knock-in mouse line for selectively targeting myelinated primary afferent neurons, enabling genetic studies of these fibers while excluding unmyelinated C fibers.

This study investigates the impact of a natural Disc1 deletion in 129S4 mice on social behavior in a semi-natural environment, finding minimal effects.

The paper identifies a fast nociceptive pathway that mediates rapid reflexive behavior but not affective pain.

The paper investigates social interactions in mice in naturalistic conditions, finding that mice in pain are socially avoided, challenging previous findings of empathy in rodent models.

The paper identifies PIEZO2-dependent mechanical pain in humans and mice, showing hair-pull pain is mediated by Aβ inputs and specific nociceptors.