Takanori Otomo

This study shows that SMC5/6-mediated plasmid silencing requires SIMC1-SLF2, while SLF1/2 is dispensable, and that LT antagonizes this repression similar to viral proteins.

The paper reports the crystal structure of a GABARAP~ATG3 conjugate, revealing a non-covalent interaction between GABARAP and the backside of ATG3's E2 catalytic center, which is important for PE conjugation.

The paper presents cryo-EM structures of AtAgo10-guide RNA complexes with and without target RNA, revealing distinct slicing mechanisms in eukaryotic AGOs compared to bacterial TtAgo.