Bramwell Coulson

The paper shows that different parts of the Drosophila larval locomotor network respond differently to heat stress during a critical period, leading to varied functional and structural changes.

The paper manipulates neuronal activity during an embryonic critical period in Drosophila and finds cell type-specific changes in intrinsic excitability that persist into larval development.

The paper identifies mitochondrial ROS and HIF-1α signaling as critical for critical period plasticity in Drosophila.

This study shows that balanced neural activity during a critical period is essential for normal circuit development, as imbalances lead to hyperexcitability and reduced network robustness.