Matthias Landgraf

Heterogeneous responses to embryonic critical period perturbations within the Drosophila larval locomotor circuit.

The paper shows that different parts of the Drosophila larval locomotor network respond differently to heat stress during a critical period, leading to varied functional and structural changes.

Neuronal excitability is permanently altered by activity manipulation during an embryonic critical period in Drosophila

The paper manipulates neuronal activity during an embryonic critical period in Drosophila and finds cell type-specific changes in intrinsic excitability that persist into larval development.

Maturation of GABAergic signalling times the opening of a critical period in Drosophila melanogaster

The paper shows that GABAergic signaling controls the timing of a critical period in Drosophila melanogaster's locomotor network, with agonists accelerating and antagonists delaying its opening.

Different mechanisms link gain and loss of kinesin functions to axonal degeneration

The paper investigates how both loss and gain of kinesin functions lead to axonal degeneration through microtubule curling in Drosophila neurons.

Mitochondrial ROS and HIF-1α signalling mediate critical period plasticity

The paper identifies mitochondrial ROS and HIF-1α signaling as critical for critical period plasticity in Drosophila.

Balance of Activity during a Critical Period Tunes a Developing Network

This study shows that balanced neural activity during a critical period is essential for normal circuit development, as imbalances lead to hyperexcitability and reduced network robustness.

Activity-regulated growth of motoneurons at the neuromuscular junction is mediated by NADPH oxidases

The paper identifies NADPH oxidases as essential for activity-regulated structural plasticity at the neuromuscular junction in Drosophila.

NADPH oxidase generated reactive oxygen species and aquaporin conduits mediate activity-regulated dendritic plasticity.

The paper identifies NADPH oxidase-generated reactive oxygen species and aquaporin conduits as mediators of activity-regulated dendritic plasticity in Drosophila motoneurons.

Synaptic specificity is collectively determined by partner identity, location and activity

The paper investigates how synaptic connections in Drosophila are formed through partner-derived cues, global positional cues, and synaptic activity, showing that all three contribute to proper circuit assembly.

Connectomics analysis reveals first, second, and third order thermosensory and hygrosensory neurons in the adult Drosophila brain

The paper identifies new thermosensory and hygrosensory glomeruli and neurons in the Drosophila brain using connectomics, revealing their connections to higher brain centers and circadian clock circuits.

Electrophysiological validation of premotor interneurons monosynaptically connected to the aCC motoneuron in the Drosophila larval CNS.

The paper validates four Drosophila premotor interneuron driver lines using electrophysiology, confirming their monosynaptic connection to the aCC motoneuron.

Motor circuit function is stabilized during postembryonic growth by anterograde trans-synaptic Jelly Belly - Anaplastic Lymphoma Kinase signaling

This study shows that Jeb-Alk signaling stabilizes motor circuit function during postembryonic growth in Drosophila by preventing excessive synaptic strengthening.

Activity manipulation of an excitatory interneuron, during an embryonic critical period, alters network tuning of the Drosophila larval locomotor circuit

The paper shows that manipulating activity of a specific excitatory interneuron during a critical period in Drosophila larval development alters network tuning, with nitric oxide signaling playing a role dependent on prior network activity.

Reactive Oxygen Species Regulate Activity-Dependent Neuronal Structural Plasticity in Drosophila

This study shows reactive oxygen species (ROS) regulate activity-dependent structural plasticity in Drosophila neurons, with DJ-1β modulating synaptic plasticity via the PTEN-PI3K pathway.