Jovica Ninkovic

Human cerebral assembloids as a model to study the interaction of glioblastoma with resident glial cells

This study develops human cerebral assembloids to model glioblastoma interactions with glial cells, revealing extracellular vesicles' role in peritumoral niche formation.

Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner

The paper shows that Hmgb2 enhances astrocyte-to-neuron conversion by regulating chromatin accessibility of neuronal maturation genes in response to growth factors.

Multimodal synapse analysis reveals limitations in transplanted neuron integration mediated by TREM2

This study shows that TREM2 deficiency rescues synaptic integration and functional maturation of transplanted neurons in an inflammatory environment.

Stab Wound Injury Elicits Transit Amplifying Progenitor-like Phenotype in Parenchymal Astrocytes

This study identifies injury-induced plastic astrocytes in mice that exhibit self-renewal and neurosphere-forming capabilities, resembling transit-amplifying progenitors in transcriptional profile.

Shared inflammatory glial cell signature after brain injury, revealed by spatial, temporal and cell-type-specific profiling of the murine cerebral cortex

The paper identifies a shared inflammatory glial cell signature after brain injury using spatial and single-cell transcriptomics in mice, showing common injury-regulated genes across astrocytes, microglia, and oligodendrocyte precursor cells.

After traumatic brain injury oligodendrocytes regain a plastic phenotype and can become astrocytes

This study shows that oligodendrocytes can convert into astrocytes after traumatic brain injury through a transitional AO cell stage, influenced by local environmental cues.

Subtle Changes in Clonal Dynamics Underlie the Age-Related Decline in Neurogenesis

This study identifies an increase in asymmetric stem cell divisions with age as a key factor in the decline of neurogenesis in adult mice.