Changuk Chung

The paper benchmarks sequencing methods to recover mosaic variants in human brain tissue and introduces RIVER to enhance variant detection across methods.

The paper identifies compartment-specific mitochondrial Ca2+ dynamics in neurons and their molecular regulators, showing how these differences affect neuronal development.

The paper uses genomic mosaicism to study clonal dynamics of trunk neural crest-derived ganglia, finding conserved developmental patterns across species.

The paper uses mosaic variant barcodes to analyze clonal dynamics in human forebrain cell types, revealing lineage relationships and clonal spread patterns.

This study identifies 69 mutated genes in malformations of cortical development using multiomic profiling of 317 brain resections and single-cell sequencing.

DeepMosaic detects mosaic single nucleotide variants without control samples using deep convolutional neural networks, achieving high accuracy and uncovering many variants missed by existing methods.

The paper evaluates brain somatic mosaicism in the adult human to identify rules governing cellular distribution during embryogenesis.

This study investigates the role of SALM1/LRFN2 in synaptic function and behavior by analyzing Lrfn2-/- mice, finding altered synaptic plasticity, inhibitory synapse development, and social communication behaviors.