Gautier Follain

Pancreatic cancer cells breach endothelial barriers through protrusion-driven invasion or endothelial retraction

This study identifies two distinct mechanisms by which pancreatic cancer cells extravasate: protrusion-driven invasion and endothelial retraction, with implications for anti-metastatic strategies.

Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity

The paper identifies a signaling axis involving SorLA, integrin, and HER2/HER3 that regulates apicobasal polarity in mucinous colorectal adenocarcinoma and shows its therapeutic relevance.

Adhesion-derived condensates control component availability to regulate adhesion dynamics

This study shows that TNS1 phase separation regulates adhesion dynamics by controlling the availability of inactive adhesion proteins through phosphorylation-dependent condensate formation.

Tissue-scale mechanics controls differentiation strategy and dynamics of epithelial multilayering

The paper shows that tissue mechanics control epithelial multilayering by regulating cell differentiation and movement strategies in the developing mouse epidermis.

Scaffold protein SHANK3 regulates endothelial cell motility and tissue mechanics

This study shows SHANK3 regulates endothelial cell motility and tissue mechanics, affecting vascular development in zebrafish and mice.

Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer

This study shows that restoring mechanophenotype or targeting YAP/TAZ can reverse malignant properties of vocal fold cancer by reducing nuclear YAP and β-catenin levels.

Cell viscosity influences hematogenous dissemination and metastatic extravasation of tumor cells

This study shows that tumor cell viscosity affects their ability to circulate and extravasate, influencing metastasis.

Fast label-free live imaging reveals key roles of flow dynamics and CD44-HA interaction in cancer cell arrest on endothelial monolayers

This study uses fast label-free live imaging and deep learning to analyze cancer cell arrest on endothelial monolayers, finding CD44-HA interactions and flow dynamics are key factors.

NanoPyx: super-fast bioimage analysis powered by adaptive machine learning

NanoPyx improves bioimage analysis speed using adaptive machine learning to optimize algorithm selection and execution.

Fast4DReg: Fast registration of 4D microscopy datasets

Fast4DReg corrects drift in 3D microscopy datasets using 2D cross-correlations, outperforming existing tools in speed and accuracy.