Disrupted chromatin architecture blocks B lymphopoiesis in Down syndrome
Zhicong Liao, Mimi Zhang, Brian Y. Soong, Bohan Zhu, Linda L. Boshans, Ke Wang, Miguel Quijada‐Álamo, Ifeoma Osakwe, Zhe Wang, Persephone Fiore, Dan Hasson, Elvin Wagenblast, Sai Ma
The paper develops ChromE-seq to study 3D chromatin architecture in fetal hematopoiesis, finding that T21 disrupts B-lineage development by altering chromatin connectivity and regulatory circuits.
bioRxiv · Oct 11, 2026 · PreprintGenomics