John D. Lee

Molecular mechanism of naturally-encoded signaling-bias at the complement anaphylatoxin receptors

This paper identifies naturally-encoded signaling bias at C5aR1 and C5aR2 receptors through structural and functional analyses, revealing molecular mechanisms underlying biased signaling in GPCRs.

Spatial pharmaco-multiomics reveals drug distribution, metabolic niches, and spatially constrained resistance in medulloblastoma

This study develops a spatial pharmaco-multiomics framework to map drug distribution, metabolic niches, and resistance mechanisms in medulloblastoma using integrated spatial and transcriptomic data.

Molecular fingerprints of a convergent mechanism orchestrating diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptors

This study identifies a convergent molecular mechanism and species-specific pharmacology in complement anaphylatoxin receptors through structural and functional analyses of ligand-receptor interactions.

Absence of receptor for advanced glycation end product (RAGE) reduces inflammation and extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

This study shows that removing RAGE signaling in SOD1G93A mice slows ALS progression, extends survival, and reduces neuroinflammation and oxidative stress.

A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models

The paper develops and validates a quantitative method using sodium fluorescein to assess BBB and BSCB integrity in neurodegenerative disease models, showing increased permeability in specific disease models.