Xiaoqing Alice Zhou

High spatial resolution 23Na-MRI for ischemic brain injury detection

This study develops a high-resolution 23Na-MRI platform using implanted RF coils to detect ischemic brain injury with improved contrast-to-noise ratio.

Spontaneous cortical vasodynamics form a multiscale propagation architecture across the awake brain

The paper analyzes vasomotor rhythms in awake mice using fMRI to show their multiscale propagation patterns across the cortex.

Vessel-Resolved Mapping of Perivascular Spaces Reveals Hierarchical Neurofluid Organization In Vivo

This paper introduces an ultra-high-resolution MRI framework to map perivascular spaces (PVS) across the whole brain, revealing their hierarchical organization along vascular trees.

High-Field Multinuclear MRI Reveals Sodium Relaxation Heterogeneity in Cortical Organoids

This study uses high-field multinuclear MRI to analyze sodium relaxation heterogeneity in cortical organoids, revealing distinct relaxation components and spatial microenvironment variations.

Neuronal-Activity-Related Sodium (NARS) fMRI Reveals Millisecond Neuronal Dynamics Beyond Hemodynamic Readouts

This paper introduces NARS-fMRI, a method that detects millisecond neuronal activity via 23Na signal changes, showing it correlates with BOLD and glutamate transients in rodent somatosensory cortex.

Smooth Muscle Dysfunction Drives Cerebrovascular Reserve Failure and End-Organ Brain Injury

This study shows that smooth muscle dysfunction caused by ACTA2 mutations leads to cerebrovascular reserve failure, increasing brain vulnerability to hypoperfusion and injury.

Cholinergic basal forebrain neurons regulate vascular dynamics and cerebrospinal fluid flux

The paper shows that cholinergic basal forebrain neurons influence vascular-CSF coupling and glymphatic flux in mice, suggesting a neurovascular mechanism for waste clearance in the brain.

High-resolution awake mouse fMRI at 14 Tesla

This paper develops a high-resolution awake mouse fMRI platform to map sensory processing in association cortices, revealing anticipatory brain activity during vibrissa stimulation.

Mapping glymphatic solute transportation through the perivascular space of hippocampal arterioles with 14 Tesla MRI

This study uses high-resolution MRI to map glymphatic transport in deep brain regions by directly infusing Gd into the lateral ventricle and analyzing PVS signal enhancements.

Mapping the Cerebrovascular Abnormality in Transgenic Alzheimer's Disease (AD) Mice with deep-learning-based super-resolution cerebral blood volume (CBV)-MRI

The paper develops a deep learning-based method to segment micro-vessels from CBV MRI images of AD mice, revealing region-specific vascular density changes in degenerated brains.

Mapping the bioimaging marker of Alzheimer's disease based on pupillary light response-driven brain-wide fMRI in awake mice

The paper uses pupillary light response-driven fMRI in awake mice to identify brain-wide biomarkers of Alzheimer's disease by analyzing altered neuromodulatory patterns and functional connectivity.

Clinical and biomarker changes in sporadic Alzheimer's disease

This study examines how amyloid-beta biomarkers and clinical profiles change in sporadic Alzheimer's disease, finding that amyloid changes are inconsistent with clinical and imaging markers during progression.