Cell BiologybioRxivPreprint
Dysregulated TGFb-ERK Signaling Drives Aberrant Extracellular Matrix Production in Noonan Syndrome-Associated Pulmonary Valve Stenosis
Clifford Z. Liu, Shrey D. Patel, Simone Sidoli…·Bruce D. Gelb
This study identifies dysregulated TGFβ-ERK signaling as a driver of aberrant extracellular matrix production in Noonan syndrome-associated pulmonary valve stenosis using iPSC models and patient tissue.