Clifford Z. Liu

This paper describes a feeder-free method to generate lymphatic endothelial cells from human iPSCs, which are transcriptionally and phenotypically similar to primary fetal LECs.

This study identifies dysregulated TGFβ-ERK signaling as a driver of aberrant extracellular matrix production in Noonan syndrome-associated pulmonary valve stenosis using iPSC models and patient tissue.

This paper describes a method to generate valvular interstitial cells from human pluripotent stem cells, showing high transcriptional similarity to primary fetal VICs and recapitulating disease features in an in vitro model.