Shrey D. Patel

This paper describes a feeder-free method to generate lymphatic endothelial cells from human iPSCs, which are transcriptionally and phenotypically similar to primary fetal LECs.

This study identifies dysregulated TGFβ-ERK signaling as a driver of aberrant extracellular matrix production in Noonan syndrome-associated pulmonary valve stenosis using iPSC models and patient tissue.

This study shows that inhibiting one-carbon metabolism in Ewing sarcoma cells leads to growth suppression through purine depletion, identifying a potential therapeutic target.