Amine Mazine

This study identifies dysregulated TGFβ-ERK signaling as a driver of aberrant extracellular matrix production in Noonan syndrome-associated pulmonary valve stenosis using iPSC models and patient tissue.

This paper describes a method to generate valvular interstitial cells from human pluripotent stem cells, showing high transcriptional similarity to primary fetal VICs and recapitulating disease features in an in vitro model.

This study generates human pluripotent stem cell-derived AVN-like pacemaker cells that replicate AVN function in vivo, suggesting their potential as biological conduction bridges for treating AV block.