Author

Alexander A. Mikryukov

University Health NetworkORCID 0000-0002-7632-9529Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Amine MazineiD· 2 shared Bruce D. GelbiD· 2 shared Clifford Z. LiuiD· 2 shared Gordon M. KelleriD· 2 shared Aditi Prasad· 1 shared Chrystalle Katte CarreoniD· 1 shared Craig A. SimmonsiD· 1 shared Daniel CharytonowicziD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCell Biology

Amine MazineORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Dysregulated TGFb-ERK Signaling Drives Aberrant Extracellular Matrix Production in Noonan Syndrome-Associated Pulmonary Valve Stenosis

Clifford Z. Liu, Shrey D. Patel, Simone Sidoli, Aditi Prasad, Daniel Charytonowicz, Amine Mazine, Alexander A. Mikryukov, Jamshid Abdul-Ghafar, Elizabeth S. Kahn, Dejauwne L. Young, George Arthur Porter Jr., Philip J. Katzman, Stephen Pruett Sanders, Chrystalle Katte Carreon, Dirk Hubmacher, , Bruce D. Gelb

This study identifies dysregulated TGFβ-ERK signaling as a driver of aberrant extracellular matrix production in Noonan syndrome-associated pulmonary valve stenosis using iPSC models and patient tissue.

bioRxiv · Jan 20, 2026 · PreprintCell Biology

Generation of Valvular Interstitial Cells from Human Pluripotent Stem Cells

Amine Mazine, Alexander A. Mikryukov, Ian Fernandes, Clifford Z. Liu, Soheil Jahangiri, Marcy Martin, Eric K. N. Gähwiler, Melanie Generali, Juliana Gomez, Neda Latifi, Yifei Miao, Yu Liu, Michael A Laflamme, Craig A. Simmons, Simon Philipp Hoerstrup, , Gordon M. Keller

This paper describes a method to generate valvular interstitial cells from human pluripotent stem cells, showing high transcriptional similarity to primary fetal VICs and recapitulating disease features in an in vitro model.

Global Cardiology Science and Practice · Oct 6, 2025Peer-reviewedCell Biology