Lorenzo Concia

Replication Timing Uncovers a Two-Compartment Nuclear Architecture of Interphase Euchromatin in Maize

The paper uses Hi-C and 3D FISH to show maize euchromatin has two distinct interphase subcompartments, early-S and middle-S, defined by replication timing and chromatin organization.

Entry and exit of Fragilariopsis cylindrus diatoms from the polar night: evidence for chromatin-mediated genome control

This study examines how the polar diatom Fragilariopsis cylindrus regulates its epigenome during the polar night, showing stable repression of transposable elements through H3K27me3 and DNA methylation.

A layer cake model for plant and metazoan chromatin

The paper compares 3D chromatin organization across species to propose a layer cake model that refines the two compartments model by identifying distinct chromatin layers.

Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis

This paper shows that H1 prevents H3K27me3 accumulation at telomeres and ITRs in Arabidopsis by restricting DNA accessibility to TRB proteins, while promoting PRC2 activity at genes.

New insights into homoeologous copy number variations in the hexaploid wheat genome

This study examines homoeologous copy number variations in hexaploid wheat, showing that triads represent core genes while dyads and tetrads are dispensable, with subgenome differences linked to post-polyploid diploidization.

Repliscan: a tool for classifying replication timing regions

Repliscan classifies replication timing regions from Repli-seq data by normalizing, filtering, and assigning replication signatures, outperforming previous methods with variable thresholds.