Svetlana P. Ikonomova

The paper introduces GROQ-seq, a high-throughput platform for linking protein function to sequencing data, and presents pilot datasets for transcription factors, polymerases, and proteases.

This study demonstrates that GROQ-seq provides reproducible, scalable measurements of protein function across different facilities.

The paper benchmarks sequence- and structure-based protein models using a unified framework, showing structure-based models outperform others in generating functional variants.

The paper uses GROQ-seq to profile function across a diverse protease library, showing robust activity across sequence divergence.

This study evaluates the risks of AI-driven protein design by testing synthetic homologs against biosecurity screening software.