Molecular BiologybioRxivPreprint
Crosstalk between the aryl hydrocarbon receptor and hypoxia inducible factor 1α pathways impairs downstream dioxin response in human islet models
Noa Gang, Kyle A. van Allen, William Glen Willmore…·Jennifer E. Bruin
This study investigates AHR-HIF1 pathway crosstalk in islet cells and finds hypoxia suppresses CYP1A1 and G6PC2 expression, with HIF1 dominating over AHR during TCDD + hypoxia co-treatment.
DOI 10.1101/2024.09.25.615065