Lars Erichsen

The paper investigates how DNA methylation and the antisense lncRNA hTAPAS regulate hTERT alternative splicing, revealing an epigenetic mechanism linking promoter methylation to splice isoform selection.

This study shows human urine-derived SIX2-positive renal progenitor cells reduce kidney fibrosis in an IRI mouse model but do not fully restore kidney function within 21 days.

This study identifies cytokine biomarkers in urine that can detect AKI early and suggests their role in regulating TP53 and SIRT1 pathways.

The paper identifies gender-specific and gender-independent cytokine markers in urine from Ghanaian CKD patients, suggesting potential biomarkers for early detection.

This study uses NBS patient-derived cerebral organoids to show that impaired p53-mediated DNA damage response contributes to microcephaly by causing neuronal apoptosis and disrupted neurogenesis.

This study uses iPSC-derived neuronal cultures with the TREM2 R47H variant to construct an Aβ-induced gene regulatory network, identifying ER-stress as a potential causal factor in LOAD.

This paper identifies and characterizes human urine-derived renal progenitor cells, revealing their molecular identity, reprogramming potential, and gene regulatory mechanisms for self-renewal and differentiation.