Greg Donahue

The paper shows H3K9me3 represses lineage-specific enhancers in progenitor cells, restricting transcription factor access to prevent inappropriate activation during development.

This study shows that increasing ACSS2 levels protects neurons from age-related and tau-induced decline by enhancing synaptic and longevity gene expression.

This study shows that Acss2 knockout mice consume less alcohol and exhibit epigenetic and transcriptional changes in the ventral striatum, particularly in males.

The paper investigates H3K9me3 heterochromatin dynamics in pluripotent cells, revealing distinct decay rates and mechanisms that maintain pluripotency.

This study shows ACSS2-mediated histone acetylation is critical for learning and memory in a mouse AD model, with acetate supplementation rescuing deficits.

The paper investigates how reducing histone acetylation in Alzheimer's disease models affects amyloid-reducing pathways and amyloid-beta secretion.

This study identifies spurious intragenic transcription as a conserved hallmark of mammalian cellular senescence and tissue aging, impacting cellular health and transcriptional networks.