Tomoko Yoshida

This study investigates the functional roles of the caudal orbitofrontal cortex (cOFC) and pregenual anterior cingulate cortex (pACC) in macaques using multimodal recordings and electrical microstimulation, finding distinct roles in decision-making and autonomic responses.

The paper uses machine learning to analyze striosome and matrix compartments in Huntington's disease model mice, revealing age-related molecular differences that may explain disease pathogenesis.

The paper identifies striosomal populations in the dorsal striatum expressing Pnoc mRNA, which are dopamine receptor D1-expressing medium spiny neurons with direct projections to midbrain dopamine neurons.

This study shows that dopamine release patterns in the dorsal striatum differ between medial and lateral regions during learning, challenging classic reinforcement learning models.

The paper identifies striosomal pathways that target substantia nigra dopamine neurons, with opposite effects on movement compared to canonical pathways.

This study shows that CB1R is essential for the postnatal development of striosome-dendron bouquets, which are critical for dopamine system connectivity, and suggests potential developmental risks from maternal use of CB1R agonists or antagonists.

This study shows that microstimulation of specific prefrontal cortex regions in non-human primates induces negative decision-making by targeting striosomes in the anterior striatum.