Sam J. Washer

This study shows human iPSC-derived microglia uptake and process tau fibrils, leading to secretion in extracellular vesicles that can seed tau aggregation in neurons.

The paper integrates QTL mapping and CRISPR screening in iPSC-derived microglia to identify genetic drivers of neurodegenerative risk by linking variants to phenotypes and gene expression.

ONE-STEP tagging enables rapid, efficient, and scalable protein tagging in diverse cell types through CRISPR-Cas9 and Bxb1 integrase, with high integration efficiency and multiplexing capabilities.

The paper uses a mouse prion model and machine learning to identify neuroprotective effects of pioglitazone in neurodegenerative disease.

This study compares Nanopore sequencing with DNA methylation microarrays to evaluate its viability for epigenetic epidemiology, finding high correlation and significant smoking-associated methylation sites.

This study examines gene expression and DNA methylation changes in human astrocytes exposed to acute and recurrent low glucose, identifying UPR-related gene activation and methylation patterns.