Author

Dmytro Shepilov

University of CambridgeORCID 0000-0002-5698-1210Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Approach:statistical model· 1

Frequent Co-Authors

Florian T. MerkleiD· 4 shared Hsiao‐Jou Cortina CheniD· 4 shared Christine RowleyiD· 3 shared Edward C. HardingiD· 3 shared Dean Swinden· 2 shared Iman D. MaliiD· 2 shared Viviana MacarelliiD· 2 shared Ália dos SantosiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersNeuroscience

Florian T. MerkleORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Regional patterns of neurodegeneration in a mouse model of proteinopathy

Dmytro Shepilov, Ibrahim Ahmed Khan, Hsiao‐Jou Cortina Chen, Ália dos Santos, Christine Rowley, Edward C. Harding, Florian T. Merkle, Sneak Peek Administrator

This study maps region-specific histopathological features of scrapie-induced neurodegeneration in mouse brain regions at early and late disease stages, identifying key markers and region-specific mechanisms.

bioRxiv · Aug 17, 2025 · PreprintNeuroscience

Unbiased preclinical phenotyping reveals neuroprotective properties of pioglitazone

Edward C. Harding, Hsiao‐Jou Cortina Chen, Dmytro Shepilov, S. Zhang, Christine Rowley, Iman D. Mali, Jiahui Chen, Natasha M. Stewart, Dean Swinden, Sam J. Washer, Andrew R. Bassett, Florian T. Merkle

The paper uses a mouse prion model and machine learning to identify neuroprotective effects of pioglitazone in neurodegenerative disease.

bioRxiv · Aug 30, 2024 · PreprintNeuroscience

GLP-1R agonists activate human hypothalamic neurons

Simone Mazzaferro, Hsiao‐Jou Cortina Chen, Olivier Cahn, Andrian Yang, Dmytro Shepilov, Eugene Seah, Jiahui Chen, Bavesh Jawahar, Constanza Alcaino, Viviana Macarelli, Iman D. Mali, John A. Tadross, Fiona Mary Gribble, Frank M. Reimann, John C. Marioni, Florian T. Merkle

This study investigates how GLP-1R agonists affect human hypothalamic neurons derived from pluripotent stem cells, finding they induce depolarization, increased firing, and gene expression changes.

bioRxiv · Apr 2, 2024 · PreprintNeuroscience

Metformin acts directly in the brain to slow features of neurodegeneration.

Edward C. Harding, Hsiao‐Jou Cortina Chen, Dmytro Shepilov, Marc Welzer, Viviana Macarelli, Alix Schwiening, Christine Rowley, Sanya Aggarwal, Dean Swinden, Deborah Kronenberg‐Versteeg, Florian T. Merkle

This study shows metformin can slow neurodegeneration features in mice, even in metabolically healthy individuals, by acting directly in the brain.

bioRxiv · Jul 18, 2023 · PreprintNeuroscience