Qian Yang

This study examines how different SETD1A mutations and genetic backgrounds affect human hippocampal neurons derived from hiPSCs, revealing divergent molecular and cellular phenotypes and contrasting mutation impacts.

The paper compares gene expression in immature neurons across species to identify human-specific features and shared biological processes.

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

This study investigates how rare mutations in the SETD1A gene affect human neurons, showing they disrupt synaptic function and may contribute to schizophrenia pathophysiology.

This study uses whole-genome sequencing to identify regulatory and novel genic variants contributing to childhood cardiomyopathy.