Angela Nicole Viaene

This study creates a longitudinal multiomic atlas of pediatric high-grade glioma, revealing distinct tumor cell states and therapeutic targets not seen in adult glioblastoma.

The paper compares gene expression in immature neurons across species to identify human-specific features and shared biological processes.

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

OpenPBTA provides a collaborative platform to genomically characterize 1,074 pediatric brain tumors and 22 cell lines, offering analysis modules and somatic datasets for research and clinical applications.

This study shows that the blood brain barrier in 22q11.2 deletion syndrome is compromised, leading to increased neuroinflammation and potential risk for neuropsychiatric disorders.