Hongjun Song

Impacts of different SETD1A mutations and genetic backgrounds on human induced pluripotent stem cell-derived hippocampal neurons

This study examines how different SETD1A mutations and genetic backgrounds affect human hippocampal neurons derived from hiPSCs, revealing divergent molecular and cellular phenotypes and contrasting mutation impacts.

Spatial mapping of RNA turnover kinetics and regulatory landscapes of mRNA stability in the mammalian brain

The paper introduces spatial NT-seq to map RNA turnover and stability in the mouse brain, revealing spatial heterogeneity and kinetics scaling mechanisms in response to ECS.

Altered development and network connectivity in a human neuronal model of 15q11.2 deletion-related neurodevelopmental disorders

This study examines 15q11.2 deletion effects on neuronal development and function using iPSC-derived neurons, finding structural and functional impairments in network connectivity and maturation.

Comparative molecular landscapes of immature neurons in the mammalian dentate gyrus across species reveal special features in humans

The paper compares gene expression in immature neurons across species to identify human-specific features and shared biological processes.

Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae

This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.

Brain-wide neuronal circuit connectome of human glioblastoma

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy

The paper shows that patient-derived glioblastoma organoids can reflect CAR-T cell treatment responses in real-time, correlating with clinical outcomes in patients.

Single-Soma Deep RNA sequencing of Human DRG Neurons Reveals Novel Molecular and Cellular Mechanisms Underlying Somatosensation

This study develops a method to sequence individual human DRG neuron somas, identifies 16 neuronal types, and reveals human-specific nociceptor types and potential drug targets.

Mutations of schizophrenia risk gene SETD1A dysregulate synaptic function in human neurons

This study investigates how rare mutations in the SETD1A gene affect human neurons, showing they disrupt synaptic function and may contribute to schizophrenia pathophysiology.

Temporal multi-modal single-cell analyses reveal dynamic interactions of CAR-T cells with glioblastoma and targeting of antigen-negative neoplastic cells

This study uses temporal multi-modal single-cell profiling to show CAR-T cells interact dynamically with glioblastoma cells, including antigen-negative ones, and reduce their proliferation through IFN-gamma.

GABAergic neuron dysregulation in a human neurodevelopmental model for major psychiatric disorders

This study investigates GABAergic neuron dysfunction in psychiatric disorder models, finding mutation-dependent synaptic deficits and shared gene expression changes in DISC1 mutant neurons.

Phase-Amplitude Coupling Detection and Analysis of Human 2-Dimensional Neural Cultures in Multi-well Microelectrode Array in Vitro

The paper analyzes phase-amplitude coupling in human 2D neural cultures to show that network-level interactions, not single neurons, drive coupling, suggesting PAC is a fundamental property of neural networks.

Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics

This study identifies G9a's noncanonical role in promoting translation of genes involved in hyperinflammation and lymphopenia in COVID-19, revealing therapeutic targets that counteract viral effects.

Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function

The paper shows that adolescent neurostimulation of dopamine circuits can reverse cognitive deficits in genetic mouse models.

Global remapping in granule cells and mossy cells of the mouse dentate gyrus

The paper investigates remapping in granule and mossy cells of the mouse dentate gyrus during foraging in different environments, finding both cell types remap robustly but through distinct mechanisms.

Cell-Type Specific Profiling of Histone Post-Translational Modifications in the Adult Mouse Striatum

The paper profiles cell-type specific histone post-translational modifications in mouse striatal neurons to uncover regulatory epigenomic features associated with neurobiological function and disease.

Gain and loss of function variants in EZH1 disrupt neurogenesis timing and cause overlapping neurodevelopmental disorders

Basal forebrain cholinergic circuits orchestrate diverse cell types in the adult dentate gyrus to support neural stem cell function and spatial memory

This study identifies cholinergic circuits that regulate neural stem cell function and spatial memory by orchestrating diverse cell types in the dentate gyrus through transcriptomic and functional analyses.

Flexible encoding of objects and space in single cells of the dentate gyrus

The paper investigates how DG cells encode spatial and object information in mice, finding cells that respond to object changes and spatial reorganization.

An All-to-All Approach to the Identification of Sequence-Specific Readers for Epigenetic DNA Modifications on Cytosine

The paper withdraws its manuscript due to the need for further experimental validation of its conclusions.

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism

This study shows SARS-CoV-2 can infect brain cells and organoids derived from human induced pluripotent stem cells, leading to cell death and inflammation, and suggests using these models to study the virus's effects on the brain.

Persistent Cyfip1 expression is required to maintain the adult subventricular zone neurogenic niche

This study shows that Cyfip1 is critical for maintaining the adult subventricular zone niche by regulating B1 cell proliferation and adherens junction proteins.

Tet2 negatively regulates memory fidelity

This study shows that Tet2 negatively regulates long-term memory fidelity by modulating DNA methylation in hippocampal neurons.

Robust Hi-C chromatin loop maps in human neurogenesis and brain tissues at high-resolution

The paper develops an improved Hi-C protocol and bias-correction pipeline to map chromatin loops in human neurogenesis and brain tissues, showing their role in neural differentiation and GWAS gene identification.

cis-Regulatory Chromatin Contacts in Neural Cells Reveal Contributions of Genetic Variants to Complex Neurological Disorders

The paper identifies cis-regulatory chromatin contacts in neural cells and links them to genetic variants associated with complex neurological disorders.

In vivo clonal analysis reveals spatiotemporal regulation of thalamic nucleogenesis

This study uses in vivo clonal analysis to show that thalamic nuclei are generated sequentially based on progenitor cell location and that intermediate progenitors produce neurons for multiple nuclei.

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

This study identifies virus- and strain-specific molecular signatures of ZIKV infection in human cortical neural progenitors, showing distinct impacts on DNA replication and apoptosis.