Guo‐li Ming

The paper introduces spatial NT-seq to map RNA turnover and stability in the mouse brain, revealing spatial heterogeneity and kinetics scaling mechanisms in response to ECS.

This study examines 15q11.2 deletion effects on neuronal development and function using iPSC-derived neurons, finding structural and functional impairments in network connectivity and maturation.

The paper compares gene expression in immature neurons across species to identify human-specific features and shared biological processes.

This study shows that lack of m6A methylation in Schwann cells causes demyelination and regenerative failure in mice.

This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.

The paper shows that in 3D forebrain organoids, neurons and neural progenitors use type I interferon signaling to limit viral spread through intercellular communication.

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

The paper shows that patient-derived glioblastoma organoids can reflect CAR-T cell treatment responses in real-time, correlating with clinical outcomes in patients.

The paper identifies antiviral immune responses in neural stem cells and shows how a neuropathogenic virus inhibits these responses in forebrain organoids.

This study develops a method to sequence individual human DRG neuron somas, identifies 16 neuronal types, and reveals human-specific nociceptor types and potential drug targets.

This study investigates how rare mutations in the SETD1A gene affect human neurons, showing they disrupt synaptic function and may contribute to schizophrenia pathophysiology.

This study uses temporal multi-modal single-cell profiling to show CAR-T cells interact dynamically with glioblastoma cells, including antigen-negative ones, and reduce their proliferation through IFN-gamma.

This study investigates GABAergic neuron dysfunction in psychiatric disorder models, finding mutation-dependent synaptic deficits and shared gene expression changes in DISC1 mutant neurons.

The paper analyzes phase-amplitude coupling in human 2D neural cultures to show that network-level interactions, not single neurons, drive coupling, suggesting PAC is a fundamental property of neural networks.

The paper shows that adolescent neurostimulation of dopamine circuits can reverse cognitive deficits in genetic mouse models.

The paper investigates remapping in granule and mossy cells of the mouse dentate gyrus during foraging in different environments, finding both cell types remap robustly but through distinct mechanisms.

This study identifies cholinergic circuits that regulate neural stem cell function and spatial memory by orchestrating diverse cell types in the dentate gyrus through transcriptomic and functional analyses.

The paper investigates how DG cells encode spatial and object information in mice, finding cells that respond to object changes and spatial reorganization.

This study shows SARS-CoV-2 can infect brain cells and organoids derived from human induced pluripotent stem cells, leading to cell death and inflammation, and suggests using these models to study the virus's effects on the brain.

This study shows that knocking out myosin IIA/B in retinal ganglion cells promotes optic nerve regeneration, with synergistic effects when combined with Lin28 overexpression.

This study shows that Cyfip1 is critical for maintaining the adult subventricular zone niche by regulating B1 cell proliferation and adherens junction proteins.

The paper develops an improved Hi-C protocol and bias-correction pipeline to map chromatin loops in human neurogenesis and brain tissues, showing their role in neural differentiation and GWAS gene identification.

The paper identifies cis-regulatory chromatin contacts in neural cells and links them to genetic variants associated with complex neurological disorders.

This study uses in vivo clonal analysis to show that thalamic nuclei are generated sequentially based on progenitor cell location and that intermediate progenitors produce neurons for multiple nuclei.