Tianyou Yao

The paper profiles individual phage transcription during E. coli infection to reveal how viral activity influences cell fate decisions between lysis and lysogeny.

The paper identifies a phage-encoded small RNA that regulates E. coli genes by hijacking host replication machinery during the phage lytic cycle.

This study introduces a genome-wide classification of regulatory modes in bacteria by analyzing transcription-replication interactions, revealing new insights into gene expression dynamics and regulatory context.

The paper shows that bacteriophage lambda uses viral replication to reliably count infecting genomes, leading to lysogenic or lytic decisions based on multiplicity of infection.