Diego Esposito

This study presents the crystal structure of SspH1 and analyzes its conformational dynamics, showing it exists in an open-closed equilibrium with substrate binding modulating state distribution but not inducing major conformational changes.

The paper identifies RING E3 pseudoligases in the TRIM protein family by analyzing their structure and ubiquitin ligase activity, revealing structural divergence that impairs their function.

This study identifies that Salmonella effector kinase SteC is activated by host-mediated phosphorylation at S379, which enhances its kinase activity and promotes actin polymerisation.