Zhu Liu

This paper introduces GZL626, a novel AR degrader that targets the N-terminal domain and RNF213-UBE2J2 complex, effectively degrading AR and AR-V7 and showing antitumor and antiviral activity.

The paper presents cryo-EM structures of the rice Pi transporter OsPHT1;11 and reveals its conformational dynamics and mechanism for phosphate uptake.

The paper presents cryo-EM structures and molecular dynamics simulations of human XPR1, revealing a channel-like mechanism for phosphate transport and linking mutations to disease.