Chaitanya K. Gavini

Organelle-specific lipid profiles influence/underlie metabolic health in a nutrition-dependent manner

This study shows that dietary fat affects mitochondrial and lipid droplet lipid profiles in skeletal muscle, with specific lipid classes linked to metabolic health and insulin resistance.

Tanycyte-mediated synapse pruning shapes hypothalamic circuits controlling metabolism.

This study identifies tanycytes as glial cells that prune synapses in the hypothalamus, affecting metabolism and body weight control.

Tanycytic annexinA1-containing extracellular vesicles control thermogenesis by orchestrating microglial and neuronal functions.

The paper identifies Annexin A1-containing extracellular vesicles from tanycytes that regulate thermogenesis and energy balance by modulating microglial and neuronal functions in obesity.

LXR agonist Prevents Peripheral Neuropathy and modifies PNS immune cells in Aged Mice

This study shows that LXR agonist GW3965 improves peripheral neuropathy in aged mice by altering macrophage cholesterol and nerve fiber structure.

Live Monitoring of Inflammation Reveals Tissue and Sex-specific Responses to Western Diet and Butyrate treatment

The paper uses a biosensor mouse model to study tissue- and sex-specific inflammation responses to Western diet and butyrate treatment in obesity.

Neuronal LXR Regulates Neuregulin-1 Expression and Sciatic Nerve-Associated Cell signaling

This study identifies neuronal LXR regulation of neuregulin-1 and its role in neuron-Schwann cell communication in obesity-associated neuropathy.