Author

Emmanuel Di Valentin

University of LiègeORCID 0000-0002-5287-7950Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alex von KriegsheimiD· 1 shared Anisa AlijuiD· 1 shared Antoine Rohrbach· 1 shared Antonela BonafinaiD· 1 shared Arnaud BlommeiD· 1 shared Chaitanya K. GaviniiD· 1 shared Chinmayi PednekariD· 1 shared Christian Seca· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

Alex von KriegsheimORCID

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3 papers

Recent·Most cited

mTORC2 stabilizes HIF-1β to coordinate metabolic adaptation in lung cancer

Morgane Paque, Ning An, Marine Leclercq, Anisa Aliju, Elodie Renaude, Domien Vanneste, Denis Heusdens, Jair Marques, Chinmayi Pednekar, Tillmann Bedau, Juan Fernández-García, Fabienne Perin, Raphael Vanleyssem, Christian Seca, Kim Eiden, , Arnaud Blomme

This study identifies mTORC2 as a convergent dependency in lung cancer that stabilizes HIF-1β to drive metabolic adaptation and tumor progression, revealing a therapeutic target in sphingolipid metabolism.

bioRxiv · Sep 3, 2026 · PreprintCancer Biology

Tanycytic annexinA1-containing extracellular vesicles control thermogenesis by orchestrating microglial and neuronal functions.

Rafik Dali, David López Rodríguez, Irina Kolotuev, Chaitanya K. Gavini, Tamara Déglise, Emmanuel Di Valentin, Antoine Rohrbach, Jeanne Buchs, Judith Estrada-Meza, Virginie Mansuy‐Aubert, Fanny Langlet

The paper identifies Annexin A1-containing extracellular vesicles from tanycytes that regulate thermogenesis and energy balance by modulating microglial and neuronal functions in obesity.

bioRxiv · Oct 12, 2025 · PreprintNeuroscience

SARS-CoV2 infection triggers reactive astrocyte states and inflammatory conditions in long-term Human Cortical Organoids

Mathilde Colinet, Ioana Chiver, Antonela Bonafina, G. Masset, Daniel Almansa, Emmanuel Di Valentin, Jean‐Claude Twizere, Laurent Nguyen, Ira Espuny-Camacho

This study shows SARS-CoV2 infects brain cells in cortical organoids, inducing reactive astrocyte states and inflammation.

bioRxiv · Apr 16, 2024 · PreprintNeuroscience