Maxime Côme

This study shows that dopamine signals in the nucleus accumbens reflect dynamic representation learning during adaptive decision-making in mice.

The paper investigates how mice generate self-initiated goal-directed choices through interactions between the ventral tegmental area, prefrontal cortex, and orbitofrontal cortex.

This study shows chronic nicotine exposure shifts decision-making strategies toward increased exploitation in a foraging task, with optogenetic manipulation of dopamine neurons replicating this effect.

This study identifies distinct dopamine circuits in the ventral tegmental area that mediate nicotine's reinforcing and anxiogenic effects through opposing responses in neurons projecting to the nucleus accumbens and amygdala.

This study shows mice generate choice variability in a deterministic task through memory-free, pseudo-random selection rather than learning complex sequences.