Author

Derek L. Stirewalt

Fred Hutch Cancer CenterORCID 0000-0003-4151-3171Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Axia SongiD· 2 shared Elizabeth A. BonneriD· 2 shared Erica A. Arriaga-GomeziD· 2 shared Paul Brent FerrelliD· 2 shared Rasika VenkataramaniD· 2 shared Robert S. WelneriD· 2 shared Rui LuiD· 2 shared Sayantani SinhaiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Axia SongORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 24, 2026

Somatic DDX41 mutations confer neomorphic splicing activity in the pathogenesis of myelodysplastic neoplasms

Rasika Venkataraman, Noemi Puccio, Tun‐Yun Hsueh…·Stanley Chun-Wei Lee

This study identifies somatic DDX41 mutations as gain-of-function alleles that drive aberrant splicing, particularly of SEPTIN7, contributing to MDS/AML pathogenesis.

DOI 10.64898/2026.09.23.753593

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintAug 14, 2025

CDK8 is a critical effector of cell fate dysregulation in SF3B1-mutant MDS

Elizabeth A. Bonner, Tun‐Yun Hsueh, Axia Song…·Stanley Chun-Wei Lee

This study identifies CDK8 mis-splicing as a driver of altered progenitor fate in SF3B1-mutant MDS, linking splicing defects to transcriptional dysregulation and lineage commitment.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky