Author

Erica A. Arriaga-Gomez

Fred Hutch Cancer CenterORCID 0000-0002-8237-6751Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Stanley Chun-Wei LeeiD· 3 shared Axia SongiD· 2 shared Derek L. StirewaltiD· 2 shared Elizabeth A. BonneriD· 2 shared Paul Brent FerrelliD· 2 shared Rasika VenkataramaniD· 2 shared Robert S. WelneriD· 2 shared Rui LuiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Stanley Chun-Wei LeeORCID

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3 papers

Recent·Most cited

Somatic DDX41 mutations confer neomorphic splicing activity in the pathogenesis of myelodysplastic neoplasms

Rasika Venkataraman, Noemi Puccio, Tun‐Yun Hsueh, Elizabeth A. Bonner, Fu-Yen Chang, Erica A. Arriaga-Gomez, Axia Song, Takero Miyagawa, Jahan A. Rahman, Oluwanifemi Akinwande, Sayantani Sinha, Ettaib El Marabti, Robert S. Welner, Rui Lu, Paul Brent Ferrell, , Stanley Chun-Wei Lee

This study identifies somatic DDX41 mutations as gain-of-function alleles that drive aberrant splicing, particularly of SEPTIN7, contributing to MDS/AML pathogenesis.

bioRxiv · Sep 24, 2026 · PreprintCancer Biology

CDK8 is a critical effector of cell fate dysregulation in SF3B1-mutant MDS

Elizabeth A. Bonner, Tun‐Yun Hsueh, Axia Song, Laura Baquero Galvis, Erica A. Arriaga-Gomez, Rasika Venkataraman, Sayantani Sinha, Evan Nguyen, Paul Brent Ferrell, Robert S. Welner, Rui Lu, H. Joachim Deeg, Derek L. Stirewalt, Sergei R. Doulatov, Stanley Chun-Wei Lee

This study identifies CDK8 mis-splicing as a driver of altered progenitor fate in SF3B1-mutant MDS, linking splicing defects to transcriptional dysregulation and lineage commitment.

bioRxiv · Aug 14, 2025 · PreprintCancer Biology

Comparing phenotypic manifolds with Kompot: Cluster-free differential expression at single-cell resolution

Dominik J. Otto, Erica A. Arriaga-Gomez, Elana Thieme, Ruijin Yang, Stanley Chun-Wei Lee, Manu N. Setty

Kompot enables cluster-free differential expression analysis in single-cell data, identifying phenotypic shifts and transcriptional changes across conditions.

bioRxiv · Jun 3, 2025 · PreprintBioinformatics