Omer Gilan

This study identifies Menin as a key regulator of oncogenic gene expression in multiple myeloma and shows that Menin inhibitors are effective in myeloma cell lines and models.

The paper identifies cofactors required by different transcription factors and promoters using CRISPR-Cas9 screens and shows that unique cofactor combinations influence transcriptional steps.

The paper introduces CRISPR-ChIP to identify chromatin factors associated with histone modifications in MLL-leukaemia, revealing distinct DOT1L complexes with oncogenic and endogenous functions.