Alan L. Hutchison

This study shows that dietary restriction in Drosophila affects diurnal rhythms and longevity through clock-controlled proteasome subunits.

The paper improves rhythm detection in sparsely sampled genome-wide expression time series using bootstrapping and empirical Bayes methods, showing better consistency than existing methods.

The paper addresses the issue of dependent p-values in rhythm detection methods for genome-wide expression time series and proposes corrections for accurate statistical significance estimation.