MeCP2 Represses the Activity of Topoisomerase IIβ in Long Neuronal Genes
Sabin A. Nettles, Yoshiho Ikeuchi, Katheryn B. Lefton, Ladan Abbasi, Alyssa Erickson, Chibueze Agwu, Thomas Papouin, Azad Bonni, Harrison W. Gabel
This study identifies a functional interaction between MeCP2 and TOP2β in neurons, showing MeCP2 inhibits TOP2β activity at long genes, which may contribute to neurodevelopmental disorders.
Cell Reports · Dec 1, 2023Peer-reviewedNeuroscience