NeurosciencebioRxivPreprint
Impaired lipoprotein secretion by APOE4 leads to lysosomal and mitochondrial dysfunction in human microglia
Jasmin S. Revanna, Karl A. Wessendorf-Rodriguez, Qiang Xiao…·Fred H. Gage
This study shows that APOE4 impairs lipoprotein secretion in microglia, leading to lysosomal and mitochondrial dysfunction and a proinflammatory phenotype.
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