Jeffrey R. Jones

Growing Macroscopic Functional Human Tissues on 3D Printed Peptide Hydrogels

This study demonstrates growing macroscopic functional human tissues on 3D-printed peptide hydrogels, enabling centimeter-scale neural organoids and directional axonal communication.

An age-preserving neuronal iSpheroid platform for modeling human aging and Alzheimer disease

This paper introduces an age-preserving neuronal iSpheroid platform that models human aging and Alzheimer's disease, revealing disease-associated metabolic changes and potential therapeutic targets.

Impaired lipoprotein secretion by APOE4 leads to lysosomal and mitochondrial dysfunction in human microglia

This study shows that APOE4 impairs lipoprotein secretion in microglia, leading to lysosomal and mitochondrial dysfunction and a proinflammatory phenotype.

Aberrant CD4+ T cell refeeding response impairs neuro-immune crosstalk in Parkinson's disease

The paper shows that PD patients have altered CD4+ T cell responses to fasting/refeeding, leading to impaired neuro-immune signaling through a dysfunctional metabolic program in neurons.

Scalable longitudinal imaging and transcriptomics of cells in dynamic enclosures

This paper develops a platform for longitudinal imaging and transcriptomics of live cells, revealing adaptive drug-resistant states and key drivers of cellular function through integrated analysis.

RUNX1 and YY1 modulate neuronal fate and energy metabolism in Alzheimer's disease

This study identifies RUNX1 and YY1 as master transcription factors modulating neuronal fate and energy metabolism in Alzheimer's disease using patient-derived induced neurons and post-mortem brain data.

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies

This study shows that inhibiting IDO1 restores hippocampal glucose metabolism and rescues cognition in Alzheimer's disease models.

Epigenome erosion in Alzheimer's disease brain cells and induced neurons

This study identifies AD-specific DNA methylation signatures and chromosomal epigenome erosion in LOAD brain cells and shows their conservation in induced neurons.

Incorporation of a nucleoside analog maps genome repair sites in post-mitotic human neurons

The paper identifies DNA repair hotspots in post-mitotic human neurons linked to genes essential for their identity and function.