Leonardo Sportelli

Genetic Risk and Resilience for Schizophrenia Stratified by Perinatal Gene Expression Predict Adult Cognitive Performance

The paper examines how schizophrenia genetic risk and resilience variants, co-expressed in the human brain, are associated with cognitive performance across development in 16,520 individuals.

Co-expression-based models improve eQTL predictions and highlightnovel transcriptome-wide genes associated with schizophrenia

The paper introduces co-expression-based models to improve eQTL predictions and identifies novel schizophrenia-associated genes using brain RNA-seq data.

Transcriptomics and proteomics of projection neurons in a circuit linking hippocampus with dorsolateral prefrontal cortex in the human brain

The paper analyzes transcriptomic and proteomic data from specific brain regions to identify molecular changes in schizophrenia, showing superior regional discrimination in transcriptomic and proteomic data.

A miR-137-related biological pathway of risk for Schizophrenia is associated with human brain emotion processing

The paper links miR-137 and its target genes to schizophrenia risk through emotion processing in the prefrontal cortex, showing allele associations with brain activation patterns.

Dopamine and schizophrenia from bench to bedside: Discovery of a striatal co-expression risk gene set that predicts in vivo measures of striatal function.

The paper identifies a striatal gene set linked to schizophrenia risk that predicts in vivo dopamine synthesis and striatal activation in neurotypical and patient cohorts.