Structural basis of substrate recognition and allosteric inhibition in human B0AT2
Yunlei Cao, Yunlong Cao, Deqiang Yao, Shaobai Li, Q Wang, Shaohua Shi, Futang Wan, Mingyue Li, Sijia Huang, Huaisheng Lu, Qin Yang, Cao Mi, Yafeng Shen, Chao Zheng, Shanshuang Chen, , Ming Lei
This study determines cryo-EM structures of B0AT2 to elucidate substrate recognition and allosteric inhibition mechanisms, revealing conserved intracellular cavities across SLC6 transporters.
bioRxiv · Jun 24, 2026 · PreprintBiophysics